• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Encapsulation process of hydrophobic substances. The present invention relates to a process by which it is possible to encapsulate hydrophobic substances, in particular oily substances, said capsules being coated by a film of calcium alginate. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2540925A1
    申请号:ES201530736
    申请日:2015-05-27
    公开日:2015-07-14
    发明作者:Ramón RAMÓN REAL；Ramón María RAMÓN FERRES
    申请人:Caviaroli SL；
    IPC主号:
    专利说明:

    P201530736
    05-27-2015
    DESCRIPTION
    Encapsulation procedure of hydrophobic substances
    The present invention relates to a process whereby it is possible to encapsulate hydrophobic substances, in particular oily substances, said capsules being coated with a calcium alginate film.
    The capsules of hydrophobic substances, in particular oily substances, of the present
    The invention is obtained by a process usually referred to as "spherification." In industrial scale spherification, for example, the substance to be encapsulated and a non-calcium alginate solution are pumped through two concentric tubes with flow rates so that a drop of the substance to be encapsulated wrapped by a film is formed. of the non-calcium alginate solution, which acts as an agent
    15 gelling agent. This drop falls into a bath that contains a source of calcium ions, forming a gel layer that contains the material to be encapsulated. Said film is formed almost instantaneously on the outside, being semi-solid and jelly-like, and keeps the encapsulated substance inside.
    An industrial spherification process is disclosed, for example, in PCT Patent Application WO 2009/109681 A1, in which food products, such as fruit pulp, are encapsulated, said food products being always encapsulated in aqueous base, is say, that the substance to be encapsulated is hydrophilic.
    However, the inventor of the present patent does not know of any spherification process in which the substance to be encapsulated is a hydrophobic substance, in particular an oily substance. It is possible that since the drop of the oily substance has a lower density than the solution of calcium ions in which the formed drop should fall, it becomes a technical problem to ensure that the drop maintains the solutions involved in a way
    30 concentric and the calcium alginate gelation reaction can occur before the substance to be encapsulated is released.
    In addition, the spherification process presents the difficulty that, when it is desired to increase the size of the drop or sphere, it tends to deform due to tension
    The surface, and when it is introduced into the calcium solution, the oil can be released and not form a concentric drop. This fact greatly affects the appearance
    P201530736
    05-27-2015
    aesthetics of these capsules, mainly when its purpose is to be used for the consumption of food products in a kitchen.
    The inventor of the present patent, after exhaustive studies, has developed a
    5 spherification process whereby it is possible to industrially obtain capsules of hydrophobic substances, in particular oily substances, with a surprisingly spherical shape and, in addition, it is possible to increase the diameter of said capsules to sizes up to 25 mm in diameter without affecting the sphericity of them.
    The process of the present invention is based on the use of a specific proportion of the inner and outer diameters of the concentric tubes that form the drop of the oily substance to be encapsulated and the gelling solution, respectively.
    Therefore, the present invention discloses a process for preparing 15 capsules of hydrophobic substances, characterized in that it comprises the following steps:
    a) preparation of the aqueous non-calcium alginate solution in which the alginate concentration is in the range of 0.05% to 5% by weight of the solution; b) preparation of the hydrophobic substance to be encapsulated;
    C) pumping the hydrophobic substance to be encapsulated and the aqueous non-calcium alginate solution through concentric tubes with a diameter ratio in the range of 1.2 to 5, the hydrophobic substance to be encapsulated being pumped through the tube inner and aqueous non-calcium alginate solution through the outer tube; d) introduction of the drop or drops formed in step (c) in an aqueous solution that
    25 contains calcium ions; e) washing, draining and packaging the capsules formed in step d).
    The process of the present invention can be used both in the food industry, as in the cosmetic, intra-pharmaceutical, chemical, pharmaceutical and any other industry.
    30 industry that requires these types of capsules.
    In the present invention hydrophobic substance is understood as any immiscible substance
    or practically immiscible in water. They can be organic or inorganic substances provided
    that are hydrophobic substances. For example, oily substances such as edible oils, macerated oils, oils are among said substances.
    5
    10
    fifteen
    twenty
    25
    30
    35
    P201530736
    05-27-2015
    essentials, resins, organic compounds not miscible in water and combinations thereof.
    For example, in the case of the food industry, the hydrophobic substance to be encapsulated may be a vegetable oil selected from the list comprising olive oil, sunflower oil, hazelnut oil, sesame oil, walnut oil, almond oil , cotton oil, avocado oil, peanut oil, canola oil, safflower oil, coconut oil, corn oil, palm oil, soybean oil and mixtures thereof.
    In addition, said vegetable oils may be mixed with dressings, aromas, flavors and other oil-soluble additives.
    Other types of oily substances that can be encapsulated using the process of the present invention are essential oils selected from the list comprising thyme oil (Thymus vulgaris), oregano oil (Origanum vulgaris), clove oil (Syzygium aromaticum), oil nutmeg (Myristica fragrans), cinnamon oil (Cinnamomum zeylanicum), bay oil (Laurus nobilis), orange oil (Citrus × sinensis), peppermint oil (Mentha x piperita), valerian oil (Valeriana officinalis), citronella oil (Cymbopogon nardos), lavender oil (Lavender angustifolia), jojoba oil (Simmondsia californica), rosemary oil (Rosemarinus officianalis), neem oil (Azadirachta indica), cottonseed oil (Gossypium hirsutum), Rosehip oil (Rosa eglanteria) or mixtures thereof.
    It is clear to one skilled in the art that the aqueous solution containing calcium ions used in the process of the present invention can be any source of calcium ions, provided it is capable of forming a calcium alginate gel that forms the film. external capsule. Among such sources of calcium ions can be mentioned, for example, calcium chloride, calcium lactate, calcium gluconate, or a mixture thereof. Preferably, the source of calcium ions is calcium chloride.
    In addition, said calcium ion solution can contain any type of additive or it can be mixed with any raw material that allows modifying the organoleptic characteristics of the capsule obtained.
    The alginate solution of the process of the present invention can be of any non-calcium alginate salt, provided that it reacts in the presence of calcium ions and forms the
    P201530736
    05-27-2015
    outer film of calcium alginate capsules. Preferably, the alginate used is sodium alginate. The pH of the alginate solution is between 2 and 14.
    An additional advantage of the process of the present invention is that all steps are performed at room temperature. An increase or decrease of the temperature, in addition to the increase in the production costs of the capsules, can affect the viscosity, density and surface tension of the oily and aqueous phases present in the process, so it would also be necessary to modify various parameters of the process to obtain the same results as at room temperature.
    In addition, by means of the process of the present invention it is possible to obtain spherical capsules comprising in its interior a hydrophobic substance surrounded by a calcium alginate film, in which the diameter of said hydrophobic substances is in the range of 1 mm to 25 mm, preferably in the range of 2 mm to 25 mm, more preferably 4 mm to 25 mm, even more preferably 6 mm to 25 mm, 8 mm to 25 mm, 10 mm to 25 mm, 12 mm at 25 mm, from 14 mm to 25 mm, from 16 mm to 25 mm, from 18 mm to 25 mm, and most preferably from 20 to 25 mm.
    EXAMPLES
    Example 1. Preparation of food capsules of olive oil according to the process of the present invention.
    In this example, olive oil was encapsulated using the process of the present invention. First, a sodium alginate solution was prepared at a concentration of 1% by weight. The drops were obtained by pumping through concentric tubes of 2 mm and 6 mm, respectively, for olive oil and sodium alginate solution. The drops fell into a solution containing calcium chloride at a concentration of 1% by weight.
    At least one spherical capsule of 6 mm in diameter was obtained, in which the outer film had a transparent appearance. This capsule is suitable for consumption, mainly in restaurants.
    P201530736
    05-27-2015
    Example 2. Preparation of sesame oil capsules.
    Sesame oil was encapsulated using the method of the present invention. A solution of sodium alginate was prepared at a concentration of 5% by weight, which contained
    5 0.1% potassium sorbate. The drops were obtained by pumping through 3 mm and 7 mm concentric tubes, respectively, for sesame oil and sodium alginate solution. The drops fell into a solution containing calcium chloride at a concentration of 2% by weight.
    10 At least one spherical capsule of 7 mm in diameter was obtained, in which the outer film had a transparent appearance.
    Example 3. Preparation of capsules containing rosehip oil.
    Rosehip oil was encapsulated using the method of the present invention. A solution of sodium alginate was prepared at a concentration of 0.5% by weight. The drops were obtained by pumping through concentric tubes of 2 mm and 9 mm, respectively, for rosehip oil and sodium alginate solution. The drops fell into a solution containing calcium chloride at a concentration of 3% in
    20 weight
    At least one spherical capsule of 10 mm in diameter was obtained, in which the outer film had a transparent appearance.
    25 Example 4. Preparation of capsules containing neem oil.
    Neem oil was encapsulated using the method of the present invention. A solution of sodium alginate was prepared at a concentration of 1% by weight. The drops were obtained by pumping through 1 mm and 2 mm concentric tubes,
    30 respectively, for neem oil and sodium alginate solution. The drops fell into a solution containing calcium chloride at a concentration of 2% by weight.
    At least one spherical capsule of 2 mm in diameter was obtained, in which the outer film had a transparent appearance.
    35
    P201530736
    05-27-2015
    Example 5. Preparation of capsules containing lavender oil.
    Lavender oil was encapsulated using the method of the present invention. A solution of sodium alginate was prepared at a concentration of 2% by weight. The drops
    5 were obtained by pumping through 5 mm and 25 mm concentric tubes, respectively, for lavender oil and sodium alginate solution. The drops fell into a solution containing calcium chloride at a concentration of 2% by weight.
    10 At least one spherical capsule 24 mm in diameter was obtained, in which the outer film had a transparent appearance.
    While the invention has been described with respect to examples of preferred embodiments, these should not be considered as limiting the invention, which will be defined by the broader interpretation of the following claims.
    权利要求:
    Claims (17)
    [1]

    1. Process for preparing capsules of hydrophobic substances, characterized
    because it includes the following stages: 5
    (to) preparation of the aqueous non-calcium alginate solution in which the alginate concentration is in the range of 0.05% to 5% by weight of the solution;
    (b) preparation of the hydrophobic substance to be encapsulated;
    (C) pumping of the hydrophobic substance to be encapsulated and the aqueous alginate solution
    10 non-calcium through concentric tubes with a ratio of diameters in the range of 1.2 to 5, the hydrophobic substance to be encapsulated being pumped through the inner tube and the aqueous non-calcium alginate solution through the outer tube;
    (d) introduction of the drop or drops formed in step (c) in an aqueous solution that
    contains calcium ions; 15 (e) washing, draining and packaging the capsules formed in step (d).
    [2]
    2. Method according to claim 1, characterized in that the hydrophobic substance to be encapsulated is selected from edible oils, macerated oils, essential oils, resins, non-water-miscible organic compounds and combinations thereof.
    twenty
    [3]
    3. Method according to claim 2, characterized in that the edible oil is selected from the list comprising olive oil, sunflower oil, hazelnut oil, sesame oil, walnut oil, almond oil, cotton oil, oil of avocado, peanut oil, canola oil, safflower oil, coconut oil, oil
    25 corn, palm oil, soybean oil and mixtures thereof.
    [4]
    Method according to claim 3, characterized in that said edible oil is mixed with dressings, aromas, flavors and other food-soluble additives for food use.
    30
    [5]
    5. Method according to claim 2, characterized in that the essential oil is selected from the list comprising thyme oil (Thymus vulgaris), oregano oil (Origanum vulgaris), clove oil (Syzygium aromaticum), nutmeg oil ( Myristica fragrans), cinnamon oil (Cinnamomum zeylanicum), bay oil (Laurus
    35 nobilis), orange oil (Citrus × sinensis), peppermint oil (Mentha x piperita), valerian oil (Valeriana officinalis), citronella oil (Cymbopogon nardos), lavender oil
    8

    (Lavender angustifolia), jojoba oil (Simmondsia californica), rosemary oil (Rosemarinus officianalis), neem oil (Azadirachta indica), cottonseed oil (Gossypium hirsutum), rosehip oil (Rosa eglanteria) or mixtures of the same.
    5
    [6]
    Method according to any of the preceding claims, characterized in that the aqueous solution containing calcium ions is selected from solutions of calcium chloride, calcium lactate, calcium gluconate, or a mixture thereof.
    Method according to claim 6, characterized in that the source of calcium ions is calcium chloride.
    [8]
    8. Method according to any of the preceding claims, characterized in that
    The alginate used is sodium alginate. fifteen
    [9]
    Method according to any of the preceding claims, characterized in that the concentration of the non-calcium alginate salt is in the range of 0.05% to 5% by weight in relation to the alginate solution.
    Method according to any one of the preceding claims, characterized in that the pH of the alginate solution is between 2 and 14.
    [11]
    11. Hydrophobic substance capsule obtained by a method, according to any
    of claims 1 to 10, characterized in that said capsule has a diameter in the range of 1 mm to 25 mm.
    [12]
    12. Capsule according to claim 11, characterized in that said capsule has a diameter in the range of 2 mm to 25 mm.
    13. Capsule according to claim 11, characterized in that said capsule has a diameter in the range of 4 mm to 25 mm.
    [14]
    14. Capsule according to claim 11, characterized in that said capsule has a
    diameter in the range of 6 mm to 25 mm. 35
    9

    [15]
    15. Capsule according to claim 11, characterized in that said capsule has a diameter in the range of 8 mm to 25 mm.
    [16]
    16. Capsule according to claim 11, characterized in that said capsule has a diameter in the range of 10 mm to 25 mm.
    [17]
    17. Capsule according to claim 11, characterized in that said capsule has a diameter in the range of 12 mm to 25 mm.
    18. Capsule according to claim 11, characterized in that said capsule has a diameter in the range of 14 mm to 25 mm.
    [19]
    19. Capsule according to claim 11, characterized in that said capsule has a
    diameter in the range of 16 mm to 25 mm. fifteen
    [20]
    20. Capsule according to claim 11, characterized in that said capsule has a diameter in the range of 18 mm to 25 mm.
    [21]
    21. Capsule according to claim 11, characterized in that said capsule has a diameter in the range of 20 mm to 25 mm.
    10
    类似技术:
    公开号 | 公开日 | 专利标题
    Wang et al.2013|Co-extrusion encapsulation of canola oil with alginate: Effect of quercetin addition to oil core and pectin addition to alginate shell on oil stability
    ES2595243B1|2017-04-06|PACKAGING PROCEDURE OF FOOD CAPSULES AND FOOD PRODUCT PACKAGING OBTAINED THROUGH THE SAME
    ES2541504B1|2016-02-01|Capsules containing two phases and procedure for obtaining them
    JP5696149B2|2015-04-08|Seamless alginate capsules
    ES2540925B1|2016-01-22|Encapsulation procedure of hydrophobic substances
    SA25B1|1999-08-15|Pharmacy capsules contain ranitidine
    JP6588193B2|2019-10-09|Capsule formulation
    JP4465308B2|2010-05-19|Sesame flavor for acidic seasoning and acidic seasoning containing the flavor
    EP3100721B1|2020-08-26|Capsule formulation
    JP6258716B2|2018-01-10|Soft capsule formulation containing hydrophobic gel
    Gaikwad et al.2021|Process optimization by response surface methodology for microencapsulation of pomegranate seed oil
    CN103040790B|2015-03-25|Preparation method of wild cactus polysaccharide poly| | microcapsules
    JP5924900B2|2016-05-25|Oil-absorbing composition, production method thereof, and method of using oil-absorbing composition.
    JP2018057329A|2018-04-12|Oil and fat composition and capsule agent
    TWI693078B|2020-05-11|Powder composition containing oily substance
    US9808478B2|2017-11-07|Control release of fat soluble antioxidants from an oral formulation and method
    JP6267066B2|2018-01-24|Controlled release soft capsule
    JP3137264U|2007-11-15|Deodorant supplement
    WO2021243188A1|2021-12-02|Powderized cannabis oil
    US925658A|1909-06-22|Preparation of chloroform in a solid condition.
    TW201603824A|2016-02-01|Solid composite volatiles capsule
    同族专利:
    公开号 | 公开日
    EP3311674A1|2018-04-25|
    WO2016189173A1|2016-12-01|
    JP2018517432A|2018-07-05|
    ES2540925B1|2016-01-22|
    US20180160719A1|2018-06-14|
    HK1253586A1|2019-06-21|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US2403547A|1942-04-15|1946-07-09|Peschardt William Juliu Syplie|Manufacture of artificial edible cherries, soft sheets, and the like|
    GB762700A|1954-05-17|1956-12-05|Alginate Ind Ltd|Improvements in or relating to encapsulation|ES2677445A1|2017-02-01|2018-08-01|María Dolores CASTRO LLAMAS|Flavored balls of olive oil |JPS518876B2|1972-10-03|1976-03-22|
    FR2703927B1|1993-04-13|1995-07-13|Coletica|Use of a transacylation reaction between an esterified polysaccharide and a polyamine to form in an aqueous medium a membrane at least on the surface of gelled particles.|
    DE10164110A1|2001-12-24|2003-07-10|Dragoco Gerberding Co Ag|Mononuclear filled microcapsules|
    NL1034260C2|2007-08-16|2009-02-17|Friesland Brands Bv|Encapsulated edible liquids.|
    FR2939012B1|2008-12-01|2015-03-27|Capsum|PROCESS FOR MANUFACTURING A SERIES OF CAPSULES, AND ASSOCIATED SERIES OF CAPSULES|
    PL216932B1|2010-12-14|2014-05-30|Inst Chemii Fizycznej Polskiej Akademii Nauk|Process for the preparation of capsules with hydrophilic core and polymer coating|US20190328019A1|2018-04-26|2019-10-31|Stephanie Ann Green|Olive Oil Pods or O2 Pods|
    法律状态:
    2016-01-22| FG2A| Definitive protection|Ref document number: 2540925 Country of ref document: ES Kind code of ref document: B1 Effective date: 20160122 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201530736A|ES2540925B1|2015-05-27|2015-05-27|Encapsulation procedure of hydrophobic substances|ES201530736A| ES2540925B1|2015-05-27|2015-05-27|Encapsulation procedure of hydrophobic substances|
    JP2018513917A| JP2018517432A|2015-05-27|2016-03-15|Method for encapsulating hydrophobic substances|
    US15/577,272| US20180160719A1|2015-05-27|2016-03-15|Process for encapsulating hydrophobic substances|
    EP16713500.3A| EP3311674A1|2015-05-27|2016-03-15|Process for encapsulating hydrophobic substances|
    PCT/ES2016/070165| WO2016189173A1|2015-05-27|2016-03-15|Process for encapsulating hydrophobic substances|
    HK18112792.5A| HK1253586A1|2015-05-27|2018-10-08|Process for encapsulating hydrophobic substances|
    [返回顶部]